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Tenofovir induced severe thrombocytopenia

更新时间:2023-08-14

【摘要】Tenofovir disoproxil fumarate is used in the management of hepatitis B and human immunodeficiency virus infection.We present a 50 years old lady,post liver transplant,who was switched over from entecavir to tenofovir,for management of hepatitis B reactivation.She developed bleeding diathesis and severe thrombocytopenia was detected on investigations.Bone marrow examination showed normocellular marrow with megakaryocytes.Tenofovir was stopped and she was started on intravenous immunoglobulin,followed by steroids.There was improvement in platlet counts.The case highlights a rare side effect of tenofovir therapy.

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